Hydrochloric Acid → HCID 11188024, compound

Participants

Reaction Steps

This compound was prepared generally following the procedure above for example 21 using 3,4-dihydro-2H-pyrano[3,3-f]quinolin-3-amine (intermediate 1b) as starting material. It was converted to the HCl salt by dissolution in ethyl acetate and addition of 1M HCl/Et2O (2.4 eq) to generate N-[3-(5-fluoro-1H-indol-3-yl)propyl]-3,4-dihydro-2H-pyrano[2,3-f]quinolin-3-amine bis-hydrochloride salt as a yellow solid: mp 300° C./dec. MS (ESI) m/z 376 [M+H]+. Elemental analysis for C23H22FN3O·2.00 HCl·0.25 H2O; Calculated: C, 61.00; H, 5.45; N, 9.28. Found: C, 61.16; H, 5.72; N, 9.00.

Provenance & Evidence