Hydrochloric Acid → HCID 11188024, compound

HRID 1765556Notes

Reaction equation

HRID 1765556 reaction equation
O1C2=C3C(=CC=C2CC(N)C1)N=CC=C3.Cl.Cl.CCOCC.Cl.Cl.[F:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][CH:30]=[C:29]2[CH2:35][CH2:36][CH2:37][NH:38][CH:39]1[CH2:52][O:51][C:42]2=[C:43]3[C:48](=[CH:49][CH:50]=[C:41]2[CH2:40]1)[N:47]=[CH:46][CH:45]=[CH:44]3>C(OCC)(=O)C.O>[F:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][CH:30]=[C:29]2[CH2:35][CH2:36][CH2:37][NH:38][CH:39]1[CH2:52][O:51][C:42]2=[C:43]3[C:48](=[CH:49][CH:50]=[C:41]2[CH2:40]1)[N:47]=[CH:46][CH:45]=[CH:44]3

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 10953452Ether hydrochlorideHCID 21107315HCID 21107315, compound2×HCID 69497615HCID 69497615, compound

Product 1

HCID 11188024HCID 11188024, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared generally following the procedure above for example 21 using 3,4-dihydro-2H-pyrano[3,3-f]quinolin-3-amine (intermediate 1b) as starting material. It was converted to the HCl salt by dissolution in ethyl acetate and addition of 1M HCl/Et2O (2.4 eq) to generate N-[3-(5-fluoro-1H-indol-3-yl)propyl]-3,4-dihydro-2H-pyrano[2,3-f]quinolin-3-amine bis-hydrochloride salt as a yellow solid: mp 300° C./dec. MS (ESI) m/z 376 [M+H]+. Elemental analysis for C23H22FN3O·2.00 HCl·0.25 H2O; Calculated: C, 61.00; H, 5.45; N, 9.28. Found: C, 61.16; H, 5.72; N, 9.00.

Workup

  1. customThis compound was prepared generally

Sources & evidence

ORD record
ord-516b98686c234d528a7c119114ba81ce
Source dataset
uspto-grants-2007_06
Patent number
US07227023B2

Reaction notes

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