Methyl iodide → HCID 22477336, compound

HRID 1765606Notes

Reaction equation

HRID 1765606 reaction equation
[CH3:1][N:2]([CH3:19])[CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][N:11]=2)[NH:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[I:20][CH3:21]>C(OCC)(=O)C.C(O)C>[I-:20].[CH3:1][N+:2]([CH3:21])([CH3:19])[CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][N:11]=2)[NH:6][C:5]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 22477333HCID 22477333, compound

Product 1

HCID 22477336HCID 22477336, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

A solution of dimethyl-(6-phenyl-5H-pyrrolo[2,3-b]pyrazin-7-ylmethyl)-amine [5.1 g, Reference Example 32] in ethyl acetate (100 mL) at 0° C. was treated with a solution of iodomethane (40 mL) in ethanol (150 mL). The resulting mixture was stirred at 0° C. for 2 hours. The precipitated solid was filtered then washed with ethyl acetate (10 mL) and then with diethyl ether (20 mL) to give the title compound as a yellow solid (4.5 g), m.p. 224–225° C.

Workup

  1. filtrationThe precipitated solid was filtered
  2. washthen washed with ethyl acetate (10 mL)

Sources & evidence

ORD record
ord-ed6454d42551484db513bf05982ad523
Source dataset
uspto-grants-2007_06
Patent number
US07227020B2

Reaction notes

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