反应详情

A solution of tert-butyl 3-(benzoylamino)piperidine-1-carboxylate (0.120 g) in DCM (5 ml) was treated with trifluoroacetic acid (5 ml) and stirred at room temperature for 6 h. The mixture was concentrated under reduced pressure to give a yellow oil which following neutralisation with aqueous ammonia solution, was purified using SPE (silica, eluting with methanol and 5% aqueous ammonia in methanol) to give the title compound (0.085 g) as an off-white solid.

1. concentrationThe mixture was concentrated under reduced pressure
2. customto give a yellow oil which
3. customwas purified
4. washSPE (silica, eluting with methanol and 5% aqueous ammonia in methanol)