Dichloromethane → HCID 131726483, compound

HRID 1765676Notes

Reaction equation

HRID 1765676 reaction equation
C([CH:8]([CH2:22]CCCN)[CH:9]([C:11]1[O:12][C:13]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)=[N:14][N:15]=1)O)(OC(C)(C)C)=O.[C:27]([OH:33])([C:29]([F:32])([F:31])[F:30])=[O:28].[CH2:34](Cl)Cl>>[OH:33][C:27]([C:29]([F:32])([F:31])[F:30])=[O:28].[N:19]1[CH:18]=[CH:17][C:16]([C:13]2[O:12][C:11]([CH:9]([CH3:34])[CH2:8][CH2:22][CH2:29][CH2:27][OH:33])=[N:15][N:14]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 69427440HCID 69427440, compound

Product 1

HCID 131726483HCID 131726483, compound

Procedure

2-(2-Boc-amino-1-hydroxyhexyl)-5-(4-pyridyl)-1,3,4-oxadiazole (950 mg, 2.62 mmol) and MeCl2 (5 ml) were mixed and TFA (1 ml) was added at room temperature. After stirring for 1 hour, the solvent and excess TFA were removed under vacuum to produce 2-amino-1-(5-(4-pyridyl-[1,3,4]oxadiazol-2-yl)-1-hexanol TFA salt (1 g); MS: 263.0 (M+1).

Workup

  1. customthe solvent and excess TFA were removed under vacuum

Sources & evidence

ORD record
ord-5e78cfbdd16f493e86f010141e741c73
Source dataset
uspto-grants-2007_06
Patent number
US07226921B2

Reaction notes

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