Diazomethane → Methyl-4-iodocinnamate

HRID 1765697Notes

Reaction equation

HRID 1765697 reaction equation
[I:1][C:2]1[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[N+](=[CH2:15])=[N-]>CO.C(OCC)C>[CH3:15][O:9][C:8](=[O:10])[CH:7]=[CH:6][C:5]1[CH:4]=[CH:3][C:2]([I:1])=[CH:12][CH:11]=1

Participants

5

Reactant 2

HCID 9550DiazomethaneHCID 35997884-Iodocinnamic acid

Product 1

HCID 582796Methyl-4-iodocinnamate

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

A stirred, cooled (ice bath) solution of 4-iodo-cinnamic Acid in methanol was treated with a solution of diazomethane in diethyl ether. The reaction mixture was allowed to warm to ambient temperature, the volatiles were-evaporated in vacuo to afford the title compound.

Workup

  1. customthe volatiles were-evaporated in vacuo

Sources & evidence

ORD record
ord-885fbbbe44cf4bea960f63f23abe9bbc
Source dataset
uspto-grants-2007_06
Patent number
US07226951B2

Reaction notes

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