反应详情

A solution of 6-bromo-8-[(cyclopropyl-formyl-amino)-methyl]-2,2,4,4-tetramethyl-chroman (Intermediate 8, 1.46 g, 4.0 mmol) in anhydrous tetrahydrofuran (30 mL) was treated with a 2M solution of borane:methylsulfide complex in tetrahydrofuran (5 mL, 10 mmol) and the resulting reaction mixture was refluxed for 2 h. It was then cooled in an ice bath, quenched cautiously with saturated aqueous sodium carbonate solution and extracted with diethyl ether. The organic phase was washed with water and brine, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product as a white solid (1.55 g, 100%).

1. temperaturewas refluxed for 2 h
2. temperatureIt was then cooled in an ice bath
3. customquenched cautiously with saturated aqueous sodium carbonate solution
4. extractionextracted with diethyl ether
5. washThe organic phase was washed with water and brine
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customevaporated in vacuo