反应详情

温度

80 °C

A solution of 2-[4-(8-hydroxy-2,2,4,4-tetramethyl-chroman-6-ylethynyl)-phenyl]-propionic acid methyl ester (Intermediate 22, 0.018 g, 0.046 mmol) in methanol (1 mL) and tetrahydrofuran (0.5 mL) was treated with a 2M solution of potassium hydroxide (1 mL, 2 mmol) and the resulting reaction mixture was stirred at 80° C. for 2 h. The volatiles were evaporated in vacuo to a residue that was neutralized with saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The organic phase was washed with water and brine, and dried over-anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product as a yellow solid (0.017 g, 100%).

1. customthe resulting reaction mixture
2. customThe volatiles were evaporated in vacuo to a residue that
3. extractionextracted with ethyl acetate
4. washThe organic phase was washed with water and brine, and dried over-anhydrous magnesium sulfate
5. filtrationfiltered
6. customevaporated in vacuo