反应详情

A solution of 8-hydroxy-4,4-dimethyl-6-trimethylsilanylethynyl-3,4-dihydro-2H-naphthalen-1-one (Intermediate 66, 2.2 g, 7.4 mmol) in methanol (20 mL) was treated with potassium carbonate (2.04 g, 14.8 mmol) and the resulting reaction mixture was stirred at ambient temperature for 5 h. The solvent was evaporated in vacuo, the residue was diluted with water and extracted with diethyl ether. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as an oil (1.58 g,˜100%).

1. customthe resulting reaction mixture
2. customThe solvent was evaporated in vacuo
3. additionthe residue was diluted with water
4. extractionextracted with diethyl ether
5. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customevaporated in vacuo