反应详情

A solution of 4-bromo-2-cyclopropylaminomethyl-benzoic acid isopropyl ester (Intermediate 119, 1.33 g, 4.26 mmol) in acetone (8 mL) was treated with potassium carbonate (2.36 g, 17.05 mmol) and methyl iodide (0.53 mL, 8.52 mmol) and the resulting reaction mixture was stirred at ambient temperature for 3 h. The volatiles were evaporated in vacuo, the residue was diluted with water and extracted with diethyl ether (×2). The combined organic phase was dried over anhydrous magnesium sulfate, filtered over a short bed of silica gel (230–400 mesh) and evaporated in vacuo to afford the title product (1.23 g, 70%).

1. customthe resulting reaction mixture
2. customThe volatiles were evaporated in vacuo
3. additionthe residue was diluted with water
4. extractionextracted with diethyl ether (×2)
5. dry with materialThe combined organic phase was dried over anhydrous magnesium sulfate
6. filtrationfiltered over a short bed of silica gel (230–400 mesh)
7. customevaporated in vacuo