反应详情

A solution of cyclopropyl-(4,4-dimethyl-6-trimethylsilanylethynyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-methyl-amine (Intermediate 167, 0.67 g, 2.62 mmol) in methanol (10 mL) was treated with potassium carbonate (1 g, 7.23 mmol) and the resulting reaction mixture was stirred at ambient temperature overnight. The volatiles were evaporated in vacuo and the residue was diluted with water and extracted with diethyl ether. The organic extract was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title product as a light yellow oil (0.5 g, 75%).

1. customthe resulting reaction mixture
2. customThe volatiles were evaporated in vacuo
3. additionthe residue was diluted with water
4. extractionextracted with diethyl ether
5. extractionThe organic extract
6. dry with materialwas dried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customevaporated in vacuo