Potassium Carbonate → 8-Ethyl-6-ethynyl-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one

HRID 1765887Notes

Reaction equation

HRID 1765887 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([C:16]#[C:17][Si](C)(C)C)[CH:6]=[C:7]2[C:12]=1[C:11](=[O:13])[CH2:10][CH2:9][C:8]2([CH3:15])[CH3:14])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([C:3]1[CH:4]=[C:5]([C:16]#[CH:17])[CH:6]=[C:7]2[C:12]=1[C:11](=[O:13])[CH2:10][CH2:9][C:8]2([CH3:14])[CH3:15])[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 211072528-Ethyl-4,4-dimethyl-6-(trimethylsilanyl)ethynyl-3,4-dihydro-2H-naphthalen-1-one2×

Product 1

HCID 211072538-Ethyl-6-ethynyl-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following General Procedure F and using 8-ethyl-4,4-dimethyl-6-(trimethylsilanyl)ethynyl-3,4-dihydro-2H-naphthalen-1-one (Intermediate 179, 0.66 g, 2.2 mmol), methanol (10 mL) and potassium carbonate (0.4 g, 2.9 mmol) the title compound was obtained as an orange oil (0.59 g, 100%).

Sources & evidence

ORD record
ord-106e95ff48634ad2a1abd5a792ca2c29
Source dataset
uspto-grants-2007_06
Patent number
US07226951B2

Reaction notes

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