反应详情

A mixture of 60 g of ethyl 2-oxobicyclo[3.1.0]hexane-6-carboxylate and 300 ml of 1N sodium hydroxide was stirred at 25°-30° C. After 2.5 hours, concentrated hydrochloric acid was added to adjust the pH to 0.8-1.2. The resulting solution was extracted with ethyl acetate. The extracts were dried over magnesium sulfate, filtered, and concentrated to give 49.1 g (98%) of the crude material. Recrystallization from 100 ml of ethyl acetate gave the title compound, mp 123.5°-128° C.

1. extractionThe resulting solution was extracted with ethyl acetate
2. dry with materialThe extracts were dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customto give 49.1 g (98%) of the crude material
6. customRecrystallization from 100 ml of ethyl acetate