反应详情

2 N sodium hydroxide (40 ml) and t-butyl dicarbonate were added at 0° C. to a solution of 2,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromate (12.0 g, 49.2 mm) in chloroform (40 ml) and water (40 ml), and the mixture was stirred at room temperature for 16 hours. Ethyl acetate was added to the resulting mixture which was then washed with a saturated saline solution and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure, and the resultant residues were formed into powder with ethyl acetate-isopropyl ether, to give the title compound (7.99 g).

1. washwas then washed with a saturated saline solution
2. dry with materialdried over anhydrous sodium sulfate
3. concentrationThe solvent was concentrated under reduced pressure