Water → HCID 21108115, compound

HRID 1766021Notes

Reaction equation

HRID 1766021 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:35])[CH2:15][CH2:16][C:17]([C:19]3[CH:28]=[C:27]4[C:22]([CH2:23][CH2:24][N:25](C(=O)C(F)(F)F)[CH2:26]4)=[CH:21][CH:20]=3)=[O:18])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].O>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:14](=[O:35])[CH2:15][CH2:16][C:17]([C:19]3[CH:28]=[C:27]4[C:22]([CH2:23][CH2:24][NH:25][CH2:26]4)=[CH:21][CH:20]=3)=[O:18])[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 21108271HCID 21108271, compound

Product 1

HCID 21108115HCID 21108115, compoundYield 90.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-[4-(4-chlorophenyl)-1-piperidinyl]-4-oxo-1-[2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl]-1-butanone (1.1 g, 2.17 mmol) and potassium carbonate (900 mg, 6.5 mmol) in a mixed solvent of water (10 ml) and methanol (40 ml) was stirred at room temperature for 2 hours and then extracted with ethyl acetate. The extract was washed with a saturated saline solution and dried over anhydrous magnesium sulfate. The solvent was distilled away under reduced pressure, whereby 810 mg of the title compound was obtained as colorless powder.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with a saturated saline solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled away under reduced pressure

Sources & evidence

ORD record
ord-6812e472cfa0401b8edbfd3318ac56b0
Source dataset
uspto-grants-2007_06
Patent number
US07229986B2

Reaction notes

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