4-Nitrophenyl chloroformate → HCID 69328481, compound

HRID 1766065Notes

Reaction equation

HRID 1766065 reaction equation
[C:1]([NH:5][C:6]([C:8]1[S:25][C:11]2[N:12]=[C:13]([S:23][CH3:24])[N:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=3)[C:10]=2[C:9]=1[NH2:26])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:28]([O:30][C:31]1[CH:36]=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=1)=[O:29]>>[C:1]([NH:5][C:6]([C:8]1[S:25][C:11]2[N:12]=[C:13]([S:23][CH3:24])[N:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:28]([O:30][C:31]4[CH:32]=[CH:33][C:34]([N+:37]([O-:39])=[O:38])=[CH:35][CH:36]=4)=[O:29])[CH:17]=3)[C:10]=2[C:9]=1[NH2:26])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 821294-Nitrophenyl chloroformateHCID 11531195HCID 11531195, compound

Product 1

HCID 69328481HCID 69328481, compound

Procedure

The reaction of tert-butyl 5-amino-2-methylthio-4-(3-hydroxyphenyl)-thieno[2,3-d]pyrimidine-6-carboxamide (example 1f, 400 mg) with p-nitro-phenyl chloroformate (207 mg) was performed according to the methods described in example 1g. Evaporation of the solvent under reduced pressure yielded the crude title compound.

Workup

  1. customEvaporation of the solvent under reduced pressure

Sources & evidence

ORD record
ord-6a11cb1e052b4cc3b939d63ceef350e7
Source dataset
uspto-grants-2007_06
Patent number
US07229990B2

Reaction notes

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