Ammonium Hydroxide → HCID 21109088, compound

HRID 1766094Notes

Reaction equation

HRID 1766094 reaction equation
Cl[C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[C:3]=1[C:19]#[N:20].[OH-].[NH4+:22]>>[NH2:22][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=2)[C:3]=1[C:19]#[N:20]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 17954505HCID 17954505, compound

Product 1

HCID 21109088HCID 21109088, compound

Procedure

A solution of 6-chloro-5-cyano-4-(3-nitrophenyl)-2-methylthio-pyrimidine (example 9b, 10.0 g) was treated with ammonium hydroxide (28% NH3 in water, 15 ml) and the mixture was stirred overnight. The formed crystals were collected by filtration and washed with water. The product was dried at 50° C. under vacuum yielding the title compound.

Workup

  1. filtrationThe formed crystals were collected by filtration
  2. washwashed with water
  3. customThe product was dried at 50° C. under vacuum

Sources & evidence

ORD record
ord-4b5e0d1131614351bde98108a2b1120d
Source dataset
uspto-grants-2007_06
Patent number
US07229990B2

Reaction notes

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