Benzyl 2-[2,6-Bis(isopropyl)phenoxycarbonyloxy]-benzoate → 2-[2,6-Bis(isopropyl)phenoxycarbonyloxy]-benzoic Acid

HRID 1766141ノート

反応式

HRID 1766141 の反応式
[CH:1]([C:4]1[CH:29]=[CH:28][CH:27]=[C:26]([CH:30]([CH3:32])[CH3:31])[C:5]=1[O:6][C:7]([O:9][C:10]1[CH:25]=[CH:24][CH:23]=[CH:22][C:11]=1[C:12]([O:14]CC1C=CC=CC=1)=[O:13])=[O:8])([CH3:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[CH:1]([C:4]1[CH:29]=[CH:28][CH:27]=[C:26]([CH:30]([CH3:32])[CH3:31])[C:5]=1[O:6][C:7]([O:9][C:10]1[CH:25]=[CH:24][CH:23]=[CH:22][C:11]=1[C:12]([OH:14])=[O:13])=[O:8])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 21110017Benzyl 2-[2,6-Bis(isopropyl)phenoxycarbonyloxy]-benzoate

生成物 1

HCID 211100152-[2,6-Bis(isopropyl)phenoxycarbonyloxy]-benzoic Acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a suspension of 10% Pd—C (100 mg) in ethyl acetate (15 mL) under nitrogen was added a solution of compound (105) (0.7 g, 1.6 mmol) in ethyl acetate (5 mL). The resulting suspension was degassed three times and then hydrogen gas was introduced. The reaction mixture was stirred under 1 atm hydrogen atmosphere for 14 h, then filtered through a small plug of celite. The filtrate was concentrated in vacuo. The crude product (106) was carried to next step without further purification.

後処理

  1. customThe resulting suspension was degassed three times
  2. additionhydrogen gas was introduced
  3. filtrationfiltered through a small plug of celite
  4. concentrationThe filtrate was concentrated in vacuo
  5. customThe crude product (106) was carried to next step without further purification

出典と根拠

ORDレコード
ord-4a6456b2f4044e969b26bd74b0827aa3
出典データセット
uspto-grants-2007_06
特許番号
US07230003B2

反応ノート

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