Oxalyl chloride → HCID 21110068, compound

HRID 1766152Notes

Reaction equation

[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[C:7]1([N:17]2[C:21]3=[N:22][CH:23]=[CH:24][CH:25]=[C:20]3C(C(O)=O)=[CH:18]2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][N:8]=1>ClCCl>[ClH:4].[Cl:4][C:2]([C:1]1[C:20]2[C:21](=[N:22][CH:23]=[CH:24][CH:25]=2)[N:17]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH:18]=1)=[O:3]

Participants

Conditions

Temperature: 20 °C

Procedure

0.61 cm3 (6.91 mmol) of oxalyl chloride was added, at a temperature in the region of 20° C., to 1.0 g (3.46 mmol) of 1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid in suspension in 30 cm3 of dichloromethane. After stirring at a temperature in the region of 20° C. for 2 h, the reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa) and used directly in the following stage.

Workup

concentrationthe reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa)

Sources & evidence

ORD record: ord-f4e84914bb324b0297ad8789583398df
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07230007B2

Reaction notes

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