Oxalyl chloride → HCID 21110072, compound

HRID 1766155Notes

Reaction equation

HRID 1766155 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][C:8]=1[N:17]1[C:21]2=[N:22][CH:23]=[CH:24][CH:25]=[C:20]2C(C(O)=O)=[CH:18]1>ClCCl>[ClH:4].[Cl:4][C:2]([C:1]1[C:20]2[C:21](=[N:22][CH:23]=[CH:24][CH:25]=2)[N:17]([C:8]2[CH:9]=[CH:10][C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:7]=2)[CH:18]=1)=[O:3]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 21110061HCID 21110061, compound

Product 1

HCID 21110072HCID 21110072, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

0.606 cm3 (6.91 mmol) of oxalyl chloride was added, at a temperature in the region of 20° C., to 1.0 g (3.46 mmol) of 1-(quinolin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid in suspension in 30 cm3 of dichloromethane. After stirring at a temperature in the region of 20° C. for 2 h, the reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa) and the residue was used directly in the following stage.

Workup

  1. concentrationthe reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa)

Sources & evidence

ORD record
ord-5c1e891c1b094060b64e1fbe0f41612c
Source dataset
uspto-grants-2007_06
Patent number
US07230007B2

Reaction notes

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