4-(3,4-Dichlorophenyl)-4-oxobutyric acid → 3-{1-[4-(3,4-dichlorophenyl)-1,4-dioxobutyl]-4-piperidinyl}-3,4-dihydro-2(1H)-quinazolinone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-(3,4-Dichlorophenyl)-4-oxobutyric acid	HCID 289763	—
Edukt	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
Edukt	3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one	HCID 11042597	—
Produkt	3-{1-[4-(3,4-dichlorophenyl)-1,4-dioxobutyl]-4-piperidinyl}-3,4-dihydro-2(1H)-quinazolinone	HCID 21109908	73%

Reaktionsschritte

Prepared analogously to Example 2 from 3,4-dichloro-γ-oxobenzenebutanoic acid and 3-(4-piperidinyl)-3,4-dihydro-2(1H)-quinazolinone in the presence of TBTU in a yield of 73% of theoretical. Colourless crystals, m.p. 224–226° C. and Rf 0.15 (El EE).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07230001B1
Quelldatensatz	uspto-grants-2007_06
ORD ID	ord-8a3e1c99b9b04ad3960217cd435489ba
Quellennotiz	uspto-grants-2007_06