1-(Diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine → 3-[(2-Aminophenylmethyl)amino]-1-(diphenylmethyl)-azetidine

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Reaction Steps

A solution of 20.0 g (0.5355 mol) of 1-(diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine in 200 ml of methanol was hydrogenated in the presence of 4 g of 5% rhodium/charcoal for 5 hours at ambient temperature. The catalyst was filtered off, the filtrate was concentrated by evaporation in vacuo. 17.7 g (96% of theoretical) of a colourless, highly viscous oil were obtained, which was further processed without any additional purification.

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