反应详情

572 ml of 40% aqueous methylamine solution and 300 ml of water were added successively to a suspension of 78.0 g (0.212 mol) of 1-(diphenylmethyl)-3-(phthalimido)-azetidine in 480 ml of ethanol. After 7 days' stirring at ambient temperature a clear solution had formed, which was freed from excess methylamine and ethanol in vacuo. The aqueous solution remaining was extracted exhaustively with ethyl acetate. The ethyl acetate extracts were dried over sodium sulphate and dried in vacuo. 45.0 g (89% of theoretical) of a colourless oil were obtained, which was further processed without any additional purification.

1. customhad formed
2. extractionThe aqueous solution remaining was extracted exhaustively with ethyl acetate
3. dry with materialThe ethyl acetate extracts were dried over sodium sulphate
4. customdried in vacuo
5. custom45.0 g (89% of theoretical) of a colourless oil were obtained
6. customwhich was further processed without any additional purification