Acetic Acid → HCID 21109915, compound

Participants

Reaction Steps

A solution of 20.0 g (0.0776 mol) of 4-(4-chloro-3-nitrophenyl)-4-oxobutanoic acid in 200 ml of 40% aqueous methylamine solution was stirred for 3 hours in a sealed vessel. Then the mixture was diluted with the same volume of water and acidified with acetic acid. The product precipitated was suction filtered, thoroughly washed with water and dried at 50° C. in a circulating air dryer. 18.5 g (95% of theoretical) of the desired compound were obtained in the form of yellow crystals.

Provenance & Evidence