Acetic Acid → HCID 21109915, compound

HRID 1766191Notes

Reaction equation

HRID 1766191 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:14])[CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16].C(O)(=O)C.[CH3:22][NH2:23]>O>[CH3:22][NH:23][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:14])[CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][C:3]=1[N+:15]([O-:17])=[O:16]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6329MethylamineHCID 18351989HCID 18351989, compound

Product 1

HCID 21109915HCID 21109915, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 20.0 g (0.0776 mol) of 4-(4-chloro-3-nitrophenyl)-4-oxobutanoic acid in 200 ml of 40% aqueous methylamine solution was stirred for 3 hours in a sealed vessel. Then the mixture was diluted with the same volume of water and acidified with acetic acid. The product precipitated was suction filtered, thoroughly washed with water and dried at 50° C. in a circulating air dryer. 18.5 g (95% of theoretical) of the desired compound were obtained in the form of yellow crystals.

Workup

  1. customThe product precipitated
  2. filtrationfiltered
  3. washthoroughly washed with water
  4. customdried at 50° C. in a circulating air dryer

Sources & evidence

ORD record
ord-f8d39cddc7024b498288c3c31b2bd267
Source dataset
uspto-grants-2007_06
Patent number
US07230001B1

Reaction notes

Loading…