反应详情

A mixture of 1.5 g (2.84 mmol) of 3-{1-[4-(4-acetylamino-3-bromophenyl)-1,4-dioxobutyl]-4-piperidinyl}-3,4-dihydro-2(1H)-quinazolinone and 150 ml of conc. hydrochloric acid was refluxed for 1 hour. The residue was digested with water, the solid precipitated was suction filtered, recrystallised from acetonitrile and dried in vacuo. Yield: 0.88 g (64% of theoretical). Rf 0.34 (El A). IR (KBr): 3471.7, 3342.4 (NH, NH2); 1666.4 (C═O) MS: M+484/486 (Br)

1. temperaturewas refluxed for 1 hour
2. customthe solid precipitated
3. filtrationfiltered
4. customrecrystallised from acetonitrile
5. customdried in vacuo