HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 17980131, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 17980125 | HCID 17980125 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 17980131 | HCID 17980131 | — |
Reaction Steps
Combine 7-bromo-5-(tert-butyldimethylsilanyloxy)-1H-indole and methylene chloride and treat with tetrabutyl ammonium fluoride (1.0 eq.) at 0° C. After the mixture is stirred for about 1 hour, pour into ethyl acetate, wash with brine, dry the organic layer over Na2SO4 and concentrate. Purify to give 7-bromo-5-hydroxy-1H-indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07230011B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-4aabc217065740c2bacf3c77be4e2bda |
| Source note | uspto-grants-2007_06 |