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HRID1766248

反应详情

EQUATION

反应方程式

HRID 1766248 的结构方程式

REACTANTS

反应物

3
结构：ClCCl
HCID6344

Dichloromethane

CH2Cl2

结构：CCCC[N+](CCCC)(CCCC)CCCC.[F-]
HCID2724141

Tetra-n-butylammonium fluoride

C16H36FN

结构：CC(C)(C)[Si](C)(C)Oc1cc(Br)c2[nH]ccc2c1
HCID17980125

未命名化合物

PRODUCTS

生成物

1
结构：Oc1cc(Br)c2[nH]ccc2c1
HCID17980131

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Combine 7-bromo-5-(tert-butyldimethylsilanyloxy)-1H-indole and methylene chloride and treat with tetrabutyl ammonium fluoride (1.0 eq.) at 0° C. After the mixture is stirred for about 1 hour, pour into ethyl acetate, wash with brine, dry the organic layer over Na2SO4 and concentrate. Purify to give 7-bromo-5-hydroxy-1H-indole.

WORKUP

后处理

  1. washwash with brine
  2. dry with materialdry the organic layer over Na2SO4
  3. concentrationconcentrate
  4. customPurify