Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Reactant | Benzenesulfonic acid 7-bromo-1H-indol-5-yl ester | HCID 86592475 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 17980106 | HCID 17980106 | — |
Reaction Steps
Combine benzenesulfonic acid 7-bromo-1H-indole-5-yl ester and 1-methyl-4-piperidone (4 eq.) in acetic acid. Heat to about 75° C. before adding 2.0 N H3PO4 (3 eq.). After about 6 hours, cool to room temperature and pour into a mixture of ammonium hydroxide in ice water. Separate the organic layer and dry over Na2SO4 and concentrated. Purify to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07230011B2 |
|---|
| Source dataset | uspto-grants-2007_06 |
|---|
| ORD ID | ord-46953f80c8524a64bb9010793e26f803 |
|---|
| Source note | uspto-grants-2007_06 |
|---|
