反应详情

温度

75 °C

Combine benzenesulfonic acid 7-bromo-1H-indole-5-yl ester and 1-methyl-4-piperidone (4 eq.) in acetic acid. Heat to about 75° C. before adding 2.0 N H3PO4 (3 eq.). After about 6 hours, cool to room temperature and pour into a mixture of ammonium hydroxide in ice water. Separate the organic layer and dry over Na2SO4 and concentrated. Purify to give the title compound.

1. temperaturecool to room temperature
2. customSeparate the organic layer
3. dry with materialdry over Na2SO4
4. concentrationconcentrated
5. customPurify