1,3-Dibromo-5-fluorobenzene → 3,5-Dibromoanisole

Sodium methoxide (4.5M solution in methanol, 8.80 ml, 41.0 mmol) was added dropwise to a stirred solution of 3,5-dibromofluorobenzene (5.00 g, 19.0 mmol, Aldrich) in N,N-dimethylformamide (95 ml) at 0° C. under a nitrogen atmosphere. The reaction was warmed to room temperature, stirred for 1 hour and then evaporated under reduced pressure. The residue was dissolved in diethyl ether and was washed with water (3×300 ml) and brine (300 ml), dried over magnesium sulphate, filtered and concentrated under reduced pressure to give the title compound as a white solid (5.13 g).

1. customevaporated under reduced pressure
2. dissolutionThe residue was dissolved in diethyl ether
3. washwas washed with water (3×300 ml) and brine (300 ml)
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure

ORD record

ord-8fe1466ca0a24e24808e8464a55a0ff2

Source dataset

uspto-grants-2007_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07230025B2