Triethylamine → 4-propyl-N-(2-thiophen-2-yl-ethyl)-benzamide

HRID 1766310노트

반응식

HRID 1766310 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][NH2:8].[CH2:9]([C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1)[CH2:10][CH3:11].C(N(CC)CC)C>C1COCC1>[CH2:9]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([NH:8][CH2:7][CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[O:17])=[CH:19][CH:20]=1)[CH2:10][CH3:11]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1042934-Propylbenzoyl chlorideHCID 116521Thiopheneethanamine

생성물 1

HCID 211103084-propyl-N-(2-thiophen-2-yl-ethyl)-benzamide수율 85.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Reaction of 2-thiopheneethylamine (50 μL, 0.42 mmol) in THF (2.5 mL) with 4-propylbenzoyl chloride (92 μL, 0.55 mmol) in presence of triethylamine (78 μL, 0.55 mmol) according to method A gave 4-propyl-N-(2-thiophen-2-yl-ethyl)-benzamide (100 mg, 0.36 mmol, 85% yield) as a off-white powder after purification on silica gel (eluent: EtOAc/hexane 5/95 to 20/80).

출처 및 근거

ORD 기록
ord-4267dedaec8f42c495cfb1f06776efbf
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07230020B2

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