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Triethylamine → 4-propyl-N-(2-thiophen-2-yl-ethyl)-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Propylbenzoyl chloride | HCID 104293 | — |
| 反応物 | Thiopheneethanamine | HCID 116521 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-propyl-N-(2-thiophen-2-yl-ethyl)-benzamide | HCID 21110308 | 85.7% |
反応手順
Reaction of 2-thiopheneethylamine (50 μL, 0.42 mmol) in THF (2.5 mL) with 4-propylbenzoyl chloride (92 μL, 0.55 mmol) in presence of triethylamine (78 μL, 0.55 mmol) according to method A gave 4-propyl-N-(2-thiophen-2-yl-ethyl)-benzamide (100 mg, 0.36 mmol, 85% yield) as a off-white powder after purification on silica gel (eluent: EtOAc/hexane 5/95 to 20/80).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07230020B2 |
| 出典データセット | uspto-grants-2007_06 |
| ORD ID | ord-4267dedaec8f42c495cfb1f06776efbf |
| 出典メモ | uspto-grants-2007_06 |