反应详情

5-Methyl-2(1H)-pyridinone (50 g, 0.46 mol) was suspended in dichloromethane (500 mL). N-bromosuccinimide (82 g, 0.46 mol) was added in portions with cooling. Addition was finished after 15 min; the mixture was stirred for 1 h at room temperature and afterwards partitioned between dichloromethane and water. Organic phases were pooled, dried with Na2SO4 and the solvent was evaporated. The residue was purified by crystallization from ethyl acetate to yield 55 g of the title compound as a light yellow solid, mp 156–161° C.

1. temperaturewith cooling
2. additionAddition
3. customafterwards partitioned between dichloromethane and water
4. dry with materialdried with Na2SO4
5. customthe solvent was evaporated
6. customThe residue was purified by crystallization from ethyl acetate