2-Methoxyethylamine → HCID 11951477, compound

HRID 1766459Notes

Reaction equation

HRID 1766459 reaction equation
CO[C:3](=[O:12])[C:4]1[CH:9]=[C:8](Br)[C:7](Cl)=[N:6][CH:5]=1.[CH3:13][O:14][CH2:15][CH2:16][NH2:17].[Cl:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1.[CH:28]1([C:31]([OH:35])([CH3:34])[CH2:32][NH2:33])[CH2:30][CH2:29]1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:8]2[C:7]([NH:17][CH2:16][CH2:15][O:14][CH3:13])=[N:6][CH:5]=[C:4]([CH:9]=2)[C:3]([NH:33][CH2:32][C:31]([CH:28]2[CH2:30][CH2:29]2)([OH:35])[CH3:34])=[O:12])=[CH:21][CH:20]=1

Participants

5

Reactant 4

HCID 80182-MethoxyethylamineHCID 742994-Chlorophenylboronic acidHCID 2764313Methyl 5-bromo-6-chloronicotinateHCID 211096921-Amino-2-cyclopropylpropan-2-ol

Product 1

HCID 11951477HCID 11951477, compound

Procedure

The title compound was synthesized in analogy to the procedure described for the preparation of Example 20, using 5-bromo-6-chloro-nicotinic acid methylester, 2-methoxy-ethylamine, 4-chlorophenyl-boronic acid and 2-cyclopropyl-2-hydroxy-propylamine (commercially available) as starting materials. MS (m/e): 404.4 (MH+).

Workup

  1. customdescribed for the preparation of Example 20

Sources & evidence

ORD record
ord-45708921d4854195a4c30b725f5a4280
Source dataset
uspto-grants-2007_06
Patent number
US07229999B2

Reaction notes

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