HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethanol → 5-(4-chloro-phenyl)-N-(3-hydroxy-2,2-dimethyl-propyl)-6-(2-methoxy-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Reactant | 1-Propanol, 3-amino-2,2-dimethyl- | HCID 117326 | — |
| Reactant | Methyl 5-bromo-6-hydroxynicotinate | HCID 2764315 | — |
| Product | 5-(4-chloro-phenyl)-N-(3-hydroxy-2,2-dimethyl-propyl)-6-(2-methoxy-ethoxy)-nicotinamide | HCID 11951834 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 102, using 5-bromo-6-hydroxy-nicotinic acid methyl ester, 2-methoxyethanol, (4-chloro-phenyl)-boronic acid and 3-amino-2,2-dimethyl-1-propanol as starting materials to yield 5-(4-chloro-phenyl)-N-(3-hydroxy-2,2-dimethyl-propyl)-6-(2-methoxy-ethoxy)-nicotinamide. MS (ISP) 393.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-ab657b8ef1554d618c31ca78ef15a1eb |
| Source note | uspto-grants-2007_06 |