HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Methoxyethanol → HCID 11949887, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Methoxyethanol | HCID 8019 | — |
| Edukt | 4-Chlorophenylboronic acid | HCID 74299 | — |
| Edukt | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Edukt | cis-2-Aminomethyl-1-cyclohexanol | HCID 12483365 | — |
| Produkt | HCID 11949887 | HCID 11949887 | — |
Reaktionsschritte
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 2-methoxyethanol, (4-chloro-phenyl)-boronic acid and cis-2-aminomethyl-1-cyclohexanol as starting materials to yield racemic cis-5-(4-chloro-phenyl)-N-(2-hydroxy-cyclohexylmethyl)-6-(2-methoxy-ethoxy)-nicotinamide. Separation with heptane/ethanol on ChiralpakAD® yielded the (−)-enantiomer, MS (ISP) 419.1 (M+H)+, αD20: −16.6° in MeOH.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07229999B2 |
| Quelldatensatz | uspto-grants-2007_06 |
| ORD ID | ord-3f139804916c434db40c2bb971aba832 |
| Quellennotiz | uspto-grants-2007_06 |