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HRID1766510

反应详情

EQUATION

反应方程式

HRID 1766510 的结构方程式

REACTANTS

反应物

4
结构：COCCO
HCID8019

2-Methoxyethanol

C3H8O2

结构：OB(O)c1ccc(Cl)cc1
HCID74299

Benzeneboronic acid, p-chloro-

C6H6BClO2

结构：O=C(O)c1cnc(Cl)c(Br)c1
HCID285433

5-bromo-6-chloronicotinic acid

C6H3BrClNO2

结构：NC[C@H]1CCCC[C@H]1O
HCID12483365

未命名化合物

PRODUCTS

生成物

1
结构：COCCOc1ncc(C(=O)NC[C@@H]2CCCC[C@@H]2O)cc1-c1ccc(Cl)cc1
HCID11949887

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, 2-methoxyethanol, (4-chloro-phenyl)-boronic acid and cis-2-aminomethyl-1-cyclohexanol as starting materials to yield racemic cis-5-(4-chloro-phenyl)-N-(2-hydroxy-cyclohexylmethyl)-6-(2-methoxy-ethoxy)-nicotinamide. Separation with heptane/ethanol on ChiralpakAD® yielded the (−)-enantiomer, MS (ISP) 419.1 (M+H)+, αD20: −16.6° in MeOH.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 75