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HRID1766522

反应详情

EQUATION

反应方程式

HRID 1766522 的结构方程式

REACTANTS

反应物

4
结构：OCC1CC1
HCID75644

Cyclopropylmethanol

C4H8O

结构：O=C(O)c1cnc(Cl)c(Br)c1
HCID285433

5-bromo-6-chloronicotinic acid

C6H3BrClNO2

结构：OB(O)c1ccc(OC(F)(F)F)cc1
HCID2734386

4-(Trifluoromethoxy)phenylboronic acid

C7H6BF3O3

结构：Cl.N[C@@H]1CCCC[C@H]1O
HCID12228412

未命名化合物

PRODUCTS

生成物

1
结构：O=C(N[C@@H]1CCCC[C@H]1O)c1cnc(OCC2CC2)c(-c2ccc(OC(F)(F)F)cc2)c1
HCID11951657

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-(trifluoromethoxy)-phenylboronic acid and (1R,2R)-2-amino-cyclohexanol hydrochloride as starting materials to yield 6-cyclopropylmethoxy-N-((1R,2R)-2-hydroxy-cyclohexyl)-5-(4-trifluoromethoxy-phenyl)-nicotinamide. MS (ISP) 451.1 (M+H)+.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 75