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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1766522Generated: October 31, 2026

Cyclopropanemethanol → 6-Cyclopropylmethoxy-N-((trans)-2-hydroxy-cyclohexyl)-5-(4-trifluoromethoxy-phenyl)-nicotinamide

https://huagongshe.com/reaction/1766522

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropanemethanolHCID 75644—
Reactant5-Bromo-6-chloropyridine-3-carboxylic acidHCID 285433—
Reactant4-(Trifluoromethoxy)phenylboronic acidHCID 2734386—
ReactantCyclohexanol, 2-amino-, hydrochloride (1:1), (1R,2R)-HCID 12228412—
Product6-Cyclopropylmethoxy-N-((trans)-2-hydroxy-cyclohexyl)-5-(4-trifluoromethoxy-phenyl)-nicotinamideHCID 11951657—

Reaction Steps

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-(trifluoromethoxy)-phenylboronic acid and (1R,2R)-2-amino-cyclohexanol hydrochloride as starting materials to yield 6-cyclopropylmethoxy-N-((1R,2R)-2-hydroxy-cyclohexyl)-5-(4-trifluoromethoxy-phenyl)-nicotinamide. MS (ISP) 451.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07229999B2
Source datasetuspto-grants-2007_06
ORD IDord-ecded711ef8d4a608cf85ddb00346dc5
Source noteuspto-grants-2007_06