Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclopropanemethanol → 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclopropanemethanol | HCID 75644 | — |
| 반응물 | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| 반응물 | 4-Fluorophenylboronic acid | HCID 285645 | — |
| 반응물 | 1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1) | HCID 21109693 | — |
| 생성물 | 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide | HCID 67012784 | — |
반응 단계
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-fluorophenylboronic acid and 1-aminomethyl-cyclopentanol hydrochloride (CAS [76066-27-8]) as starting materials to yield 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide. MS (ISP) 385.3 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07229999B2 |
| 출처 데이터셋 | uspto-grants-2007_06 |
| ORD ID | ord-871e7b07416649d5a4cece42dc05d711 |
| 출처 메모 | uspto-grants-2007_06 |