Cyclopropanemethanol → HCID 21109689, compound

HRID 1766562Notes

Reaction equation

HRID 1766562 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:9]([OH:11])=O)[CH:5]=[N:6][C:7]=1Cl.[OH:12][CH2:13][CH:14]1[CH2:16][CH2:15]1.[F:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1.Cl.[NH2:28][CH2:29][C:30]([CH:33]1[CH2:36][CH2:35][CH2:34]1)([OH:32])[CH3:31]>>[CH:33]1([C:30]([OH:32])([CH3:31])[CH2:29][NH:28][C:9](=[O:11])[C:4]2[CH:3]=[C:2]([C:21]3[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=3)[C:7]([O:12][CH2:13][CH:14]3[CH2:16][CH2:15]3)=[N:6][CH:5]=2)[CH2:36][CH2:35][CH2:34]1

Participants

5

Reactant 4

HCID 75644CyclopropanemethanolHCID 2854335-Bromo-6-chloropyridine-3-carboxylic acidHCID 2856454-Fluorophenylboronic acidHCID 21109690912454-49-0

Product 1

HCID 21109689HCID 21109689, compound

Procedure

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-fluorophenylboronic acid and 1-amino-2-cyclobutyl-propan-2-ol hydrochloride as starting materials to yield (RS)-N-(2-cyclobutyl-2-hydroxy-propyl)-6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-nicotinamide. MS (ISP) 399.0 (M+H)+.

Workup

  1. customThe title compound was synthesized in analogy to Example 75

Sources & evidence

ORD record
ord-3c73b29630ed4ddb912bcaa737bc1b0c
Source dataset
uspto-grants-2007_06
Patent number
US07229999B2

Reaction notes

Loading…