Cyclopropanemethanol → HCID 21109686, compound

HRID 1766568Notes

Reaction equation

HRID 1766568 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:9]([OH:11])=O)[CH:5]=[N:6][C:7]=1Cl.[OH:12][CH2:13][CH:14]1[CH2:16][CH2:15]1.[F:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1.[NH2:27][CH2:28][C:29]([CH3:35])([OH:34])[C:30]([F:33])([F:32])[F:31]>>[CH:14]1([CH2:13][O:12][C:7]2[C:2]([C:21]3[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=3)=[CH:3][C:4]([C:9]([NH:27][CH2:28][C:29]([OH:34])([CH3:35])[C:30]([F:33])([F:32])[F:31])=[O:11])=[CH:5][N:6]=2)[CH2:16][CH2:15]1

Participants

5

Reactant 4

HCID 75644CyclopropanemethanolHCID 2854335-Bromo-6-chloropyridine-3-carboxylic acidHCID 2856454-Fluorophenylboronic acidHCID 136207593-Amino-1,1,1-trifluoro-2-methylpropan-2-ol

Product 1

HCID 21109686HCID 21109686, compound

Procedure

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropane, 4-fluorophenylboronic acid and 3-amino-1,1,1-trifluoro-2-methyl-propan-2-ol (CAS [354-68-7]) as starting materials to yield (RS)-6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-nicotinamide. MS (ISP) 413.3 (M+H)+.

Workup

  1. customThe title compound was synthesized in analogy to Example 75

Sources & evidence

ORD record
ord-8439e1eea5084de9956a4df85b2a7305
Source dataset
uspto-grants-2007_06
Patent number
US07229999B2

Reaction notes

Loading…