HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanol → HCID 21109686, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 3-Amino-1,1,1-trifluoro-2-methylpropan-2-ol | HCID 13620759 | — |
| Product | HCID 21109686 | HCID 21109686 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropane, 4-fluorophenylboronic acid and 3-amino-1,1,1-trifluoro-2-methyl-propan-2-ol (CAS [354-68-7]) as starting materials to yield (RS)-6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-nicotinamide. MS (ISP) 413.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07229999B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-8439e1eea5084de9956a4df85b2a7305 |
| Source note | uspto-grants-2007_06 |