Procef → Cefprozil hydrate

HRID 1766582Notes

Reaction equation

HRID 1766582 reaction equation
[CH3:1]/[CH:2]=[CH:3]/[C:4]1[CH2:24][S:23][C@@H:7]2[C@H:8]([NH:11][C:12]([C@H:14]([NH2:22])[C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)=[O:13])[C:9](=[O:10])[N:6]2[C:5]=1[C:25]([OH:27])=[O:26]>CN(C=O)C>[CH3:1]/[CH:2]=[CH:3]/[C:4]1[CH2:24][S:23][C@@H:7]2[C@H:8]([NH:11][C:12]([C@H:14]([NH2:22])[C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)=[O:13])[C:9](=[O:10])[N:6]2[C:5]=1[C:25]([OH:27])=[O:26].[OH2:10]

Participants

3

Reactant 1

HCID 5281006Procef

Product 1

HCID 6436628Cefprozil hydrate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

The aqueous solution containing Cefprozil as obtained above is converted to its DMF solvate as per the method disclosed in U.S. Pat. No. 4,694,079. The wet DMF solvate without drying is desolvated by stirring with a mixture of demineralised water (75 ml) and ethyl acetate (45 ml) for 60 minutes. The product is filtered and dried to give Cefprozil monohydrate in the form of an off white to pale yellow crystalline powder.

Workup

  1. customas obtained
  2. customwithout drying
  3. filtrationThe product is filtered
  4. customdried

Sources & evidence

ORD record
ord-aff8522989b3425996446b0779d57fe8
Source dataset
uspto-grants-2007_06
Patent number
US07230097B2

Reaction notes

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