反应详情

2-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy) benzaldehyde (2.03 g) was dissolved in dichloromethane (80 mL). To the solution was added dropwise a 1 mol/L solution of boron trichloride in dichloromethane (20 mL) under ice-cooling with stirring. The reaction mixture was stirred at room temperature for 24 hours. To the reaction mixture was added dropwise methanol (10 mL) under ice-cooling with stirring. After adding diluted hydrochloric acid, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (1.45 g).

1. temperaturecooling
2. stirringThe reaction mixture was stirred at room temperature for 24 hours
3. temperaturecooling
4. stirringwith stirring
5. extractionthe reaction mixture was extracted with ethyl acetate
6. washThe organic layer was washed with brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customThe solvent was removed under reduced pressure