2-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy)benzaldehyde → HCID 69427273, compound

HRID 1766656Notes

Reaction equation

HRID 1766656 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-:24])=[O:23])=[C:17]3[C:13]=2[CH2:14][CH2:15][CH2:16]3)=[CH:7][C:4]=1[CH:5]=O.[Br-].[F:26][C:27]1[CH:28]=[C:29]([CH:50]=[CH:51][C:52]=1[O:53][CH3:54])[CH2:30][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>>[F:26][C:27]1[CH:28]=[C:29]([CH:30]=[CH:5][C:4]2[CH:7]=[C:8]([CH:9]=[CH:10][C:3]=2[O:2][CH3:1])[O:11][C:12]2[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-:24])=[O:23])=[C:17]3[C:13]=2[CH2:14][CH2:15][CH2:16]3)[CH:50]=[CH:51][C:52]=1[O:53][CH3:54]

Participants

3

Reactant 2

HCID 230312052-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy)benzaldehydeHCID 23031264HCID 23031264, compound

Product 1

HCID 69427273HCID 69427273, compound

Procedure

4-{3-[2-(3-Fluoro-4-methoxyphenyl)vinyl]-4-methoxyphenoxy}-5-methyl-7-nitroindane was prepared in a similar manner to those described in Reference Example 15 using 2-methoxy-5-(5-methyl-7-nitroindan-4-yloxy) benzaldehyde instead of 2-benzyloxy-5-(5-methyl-7-nitroindan-4-yloxy) benzaldehyde and using (3-fluoro-4-methoxybenzyl)triphenylphosphonium bromide instead of furfuryltriphenylphosphonium bromide.

Sources & evidence

ORD record
ord-6d99f8b22685463ca16c72fa10cbf58f
Source dataset
uspto-grants-2007_06
Patent number
US07230031B2

Reaction notes

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