Phenylacetic Acid → 1-[2-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy)phenyl]-2-phenylethanone

HRID 1766688Notes

Reaction equation

HRID 1766688 reaction equation
[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:6]([O:7][C:8]2[C:16]([CH3:17])=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[C:13]3[C:9]=2[CH2:10][CH2:11][CH2:12]3)=[CH:5][CH:4]=1.[C:23]1([CH2:29][C:30](O)=[O:31])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:6]([O:7][C:8]2[C:16]([CH3:17])=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[C:13]3[C:9]=2[CH2:10][CH2:11][CH2:12]3)=[CH:5][C:4]=1[C:30](=[O:31])[CH2:29][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 999Phenylacetic AcidHCID 230311142,3-Dihydro-4-(4-methoxyphenoxy)-5-methyl-7-nitro-1H-indene

Product 1

HCID 211105581-[2-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy)phenyl]-2-phenylethanone

Procedure

The title compound was prepared in a similar manner to those described in Reference Example 56 using 4-(4-methoxyphenoxy)-5-methyl-7-nitroindane instead of ethyl N-[7-(4-methoxyphenoxy)-6-methylindan-4-yl]malonamate and using phenylacetic acid instead of 4-fluorophenylacetic acid.

Sources & evidence

ORD record
ord-8b37322037a04cedaa028d04dfc5cc72
Source dataset
uspto-grants-2007_06
Patent number
US07230031B2

Reaction notes

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