Sodium Hydroxide → HCID 23693670, compound

HRID 1766695Notes

Reaction equation

HRID 1766695 reaction equation
[OH:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][C:7]2[C:8]([CH3:22])=[CH:9][C:10]([NH:16][C:17](=[O:21])[C:18]([OH:20])=[O:19])=[C:11]3[C:15]=2[CH2:14][CH2:13][CH2:12]3)=[CH:4][C:3]=1[CH:25]([CH3:27])[CH3:26].[OH-].[Na+:29]>C(O)C>[OH:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][C:7]2[C:8]([CH3:22])=[CH:9][C:10]([NH:16][C:17](=[O:21])[C:18]([O-:20])=[O:19])=[C:11]3[C:15]=2[CH2:14][CH2:13][CH2:12]3)=[CH:4][C:3]=1[CH:25]([CH3:27])[CH3:26].[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10287060HCID 10287060, compound

Product 1

HCID 23693670HCID 23693670, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-[7-(4-hydroxy-3-isopropylphenoxy)-6-methylindan-4-yl]oxamic acid (2.25 g) was dissolved in ethanol (20 mL). Adding a 1 mol/L aqueous solution of sodium hydroxide (6.09 mL), the mixture was stirred for 5 min. The reaction mixture was evaporated under reduced pressure to dryness. Adding water (0.115 mL) and diisopropyl ether (20 mL), the residue was stirred for 3 hours. The precipitate was filtrated to give the title compound (2.4 g).

Workup

  1. customThe reaction mixture was evaporated under reduced pressure to dryness
  2. stirringAdding water (0.115 mL) and diisopropyl ether (20 mL), the residue was stirred for 3 hours
  3. filtrationThe precipitate was filtrated

Sources & evidence

ORD record
ord-659b741ed2ba4c618b1cf8796e78e727
Source dataset
uspto-grants-2007_06
Patent number
US07230031B2

Reaction notes

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