3-(Benzyloxy)-5-phenylpyridin-2-amine → 2-Amino-5-phenylpyridin-3-ol

HRID 1766702ノート

反応式

HRID 1766702 の反応式
C([O:8][C:9]1[C:10]([NH2:21])=[N:11][CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:14]=1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[NH2:21][C:10]1[C:9]([OH:8])=[CH:14][C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:12][N:11]=1

参加物

4

反応物 1

HCID 103787373-(Benzyloxy)-5-phenylpyridin-2-amine

生成物 1

HCID 211113862-Amino-5-phenylpyridin-3-ol収率 93%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

To a solution of 3-benzyloxy-5-phenyl-pyridin-2-ylamine (Example I-87, 3.27 g, 11.8 mmol) in methanol (30 mL) was added Pd(OH)2 (2.5 g, 2.37 mmol). The mixture was degassed and charged with hydrogen three times, and then stirred under hydrogen balloon for 5 hr. The reaction was filtered through a celite pad, washed with methanol, and condensed. After high vacuum dry, 2-amino-5-phenyl-pyridin-3-ol was obtained (2.04 g, 93% yield). MS m/z 187 [M+1].

後処理

  1. customThe mixture was degassed
  2. additioncharged with hydrogen three times
  3. filtrationThe reaction was filtered through a celite pad
  4. washwashed with methanol, and condensed
  5. customAfter high vacuum dry

出典と根拠

ORDレコード
ord-629fb696c1ab46cd8701861cb46ee274
出典データセット
uspto-grants-2007_06
特許番号
US07230098B2

反応ノート

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